It’s difficult to imagine that a sector of our government wouldn’t have the best interests of it’s American citizens at heart. However, with the recent attacks against Kratom powder, the biased agenda of the FDA makes it hard to believe they want the best for us.
If you have been following the Kratom story for any length of time, especially since 2016, you can begin to understand there’s something going on…and the FDA doesn’t want you to know about it. This is especially true for people who are curious about Kratom and its benefits.
This is not an attack against our Food and Drug Association. This is merely my own opinion after watching them closely for the past two years. Something doesn’t add up. When it all boils down to the nuggets and cheese, this is what the FDA doesn’t want you to know about this miracle plant.
#1 – Uncontaminated Kratom is Safe
In the past, the FDA has released reports about Kratom being contaminated. There are several floating around the web. Here are the ones I could find:
Perhaps one of the most concerning facts about the entire argument of the FDA is there are vendors out there who aren’t testing their Kratom. As mentioned in the links above, the FDA recalled Kratom products from several vendors which tested positive for harmful contaminants. On a grand scale, the FDA suggests what the consumer should do about these outbreaks. In my opinion, it was another way to create a panic about “harmful” Kratom within the public eye.
However, what the FDA doesn’t want the general public to know is how uncontaminated Kratom powder is safe. In a recent article, the NIDA reported that uncontaminated Kratom isn’t harmful at all. Immediately after this post went live, something happened in September that made them edit their article and take this specific section down. Fortunately, we have proof that the NIDA did, in fact, publish this.
It is evident that the FDA is trying to keep these facts away from the public by blurring the truth. If you think about it, this natural and organic plant has sustained itself and has been used for a variety of purposes for thousands of years. This should tell you something.
#2 – Kratom Is An Atypical Opioid
In your brain there are compounds called endogenous opioids which activate opioid receptors. These proteins activate a certain number of reactions such as general mood, stress release, social interactions, and of course, pain responses.
The body experiences pain. Whether it is physical pain like back pain or neck pain, or whether it is psychological pain, such as depression, there is a need for relief in these areas of our lives.
However, the problem with opioid agonists is that they offer some serious side effects such as addiction, which creates a another problem.. The FDA has classified Kratom as an opioid which leads people to believe it holds a long list of problems for the user as regular opioids do.
Dr. Andrew Kruegel studies molecular biology at Columbia University and has done extensive research on Kratom says this:
In the opioid field, we believe that compounds typically known as atypical opioids modulate the same systems in your brain, but do so in a different and unique matter compared to classical drugs like morphine, may provide a solution to alleviate some of those negative side effects while still providing therapeutic benefits.
In this video, Andrew Kruegel explains the necessity of atypical opioids and how a potential source is through the use of Kratom. Dr. Kruegel explains how Kratom is a biased agonists where it activates the mu opioid receptor and targets the G-protein pathway and avoids turning on the arresting pathway.
Dr. Kruegel gives a great explanation of describing this in layman’s terms below:
The best analogy of this is perhaps two different lamps with two different switches. A red lamp and a green lamp. Kratom is able to turn on only the green lamp, but not turn on the red lamp which leads to side effects.
The FDA wants people who are less educated about Kratom to focus on the negatives of opioids. In fact, they want to keep quiet the fact that Kratom is a partial agonist, meaning it only turns on the receptor halfway. Amazingly, the FDA compares Kratom to other opioids like morphine, which is simply inaccurate. According to science, calling Kratom atypical is the difference between night and day when comparing it to a “regular” opioid. Recently, the FDA thought they provided credible data against Kratom, however, were caught by the American Kratom Association by not justifying any of their claims against this plant. Again, blurring the truth.
#3 – FDA Used Molecular Modeling To Back An Argument Against Kratom
In order to back their argument with “facts” the FDA created a computer model to stack the odds in their favor. First of all, as you may have imagined, a computer model can be programmed to say what you want it to say. Secondly, computers are not humans (in case you didn’t know), and the lack of real evidence can be seen through this modeling.
One of the best arguments against the FDA’s molecular modeling was written by Derek Lowe. Mr. Lowe expresses his disdain for the way the FDA went about modeling this structure.
So as an industrial medicinal chemist, I have some problems with the way the FDA is making its case here. It’s true that computational models of drug function have become more common, but “reliable” is a tricky word. If these things were truly reliable, to the point that you’d be comfortable setting government policy according to their results, then we folks in the drug industry wouldn’t have to physically screen so many new compounds in actual assays.
In essence, computational models are unreliable at best, and does not give the full story of the model in question. But that’s another thing the FDA doesn’t want you to know. They want you to continue to completely trust their judgement on matters such as Kratom.
When it comes to modulation of natural products there are a lot of factors which come into play and a computer is the furthest test to the truth in the scientific field. It’s just not accurate, and when it comes to the past two years, the Kratom community wants to have all of the best tools to help spread positive words about Kratom.
Do you think the FDA has a biased agenda when it comes to the natural plant Kratom? One could only hope that the education given by the American Kratom Association and the Botanicals Education Alliance will help more people understand the potential benefits of Kratom. However, if the FDA has their way, the real truth about Kratom will never get to people who could really use it.