The Difference Between Mitragynine and 7-Hydroxymitragynine Kratom Alkaloids

Break out your lab coats – today we’re tackling a little Kratom science. We’re taking a look at how Kratom works in the body, especially the difference between Mitragynine and 7-Hydroxymitragynine. These two indole alkaloids account for nearly all of Kratom’s effects. Understanding them can help you decide what types of Kratom products are best for you.

We’re Kats Botanicals, your Kratom alkaloid expert guides today. If you’ve been wondering about the difference between Mitragynine and 7-Hydroxymitragynine, we’ve got it covered right here.

Alkaloids & Kratom Use

Explorations of the Mitragyna alkaloids means considering each alkaloid and its behavioral effects and understanding Kratom as a whole. When we discuss strains of Kratom, we’re looking at the pharmacology of the Kratom leaf and how, wholly, it can affect human health. To get a clearer picture of exactly how Kratom may make us feel or provide relief, we need to break it down to its active parts, primarily the individual alkaloids in Kratom.

• How do the alkaloids metabolize?
• What receptors do they utilize, and how strong is that affinity?
• What are the effects that result from these molecular activities in the body?
• Essentially, how can they be harnessed for the best therapeutic use?

While there are over 40 different Kratom alkaloids, the two most important for wellness are the alkaloids Mitragynine and 7-Hydroxymitragynine, also known as MIT and 7-OH.

What Is Mitragynine (MIT)?

Mitragynine is the primary, most abundant alkaloid found in Mitragyna speciosa leaf, commonly known as Kratom. Mitragynine makes up about 66% of Thai Kratom and around 12% of Indonesian Kratom. Therefore, Mitragynine has the most impact of Kratom alkaloids. It was Ellen Field, a medicinal chemist at the University of Edinburgh, who first isolated Mitragynine in 1921. This is pretty interesting since cannabinoids like CBD and THC found in cannabis weren’t isolated until the 1940s. This demonstrates the long history and interest in the potential of Mitragynine.

The potential effects of Mitragynine are similar to those of Kratom on the whole:

• Dual-effects on energy levels which are directly tied to Kratom dosage.
• Notable effects on disposition, sociability, and well-being.
• Relief from discomfort and lingering stress.

Because of Kratom’s versatility and the potential therapeutic applications of Mitragynine, interest has skyrocketed in the West in recent decades.

Find out if Kratom is legal where you live.

Important Notes on the Metabolism of Mitragynine

Here’s the “white lab coat” stuff if you’re interested. (There’s loads more science we could share, but we’re keeping it brief. You’re welcome.)

• Mitragynine is an indole alkaloid found in Kratom. “Indole alkaloids” are a class of structurally similar molecules that impart various bodily activities.
• Mitragynine interacts with the mu opioid receptors in the body, which are the same pathways attributed to some analgesic and joyful effects.
• Mitragynine may have an inhibitory effect on the enzyme P-glycoprotein (P-gp), which underscores the importance of limiting the use of certain other drugs while taking Kratom. (This inhibitory action can slow the release of some drugs from your cells.)
• One Kratom study demonstrated that the effects of selected indole-based Kratom alkaloids, specifically Mitragynine, “can induce antinociception* by acting in the brain”.

Antinociception definition: “the action or process of blocking the detection of a painful or injurious stimulus by sensory neurons”.

What Is 7-Hydroxymitragynine (7-OH)?

Of the total alkaloid content in the Kratom leaf, only about 2% is 7-Hydroxymitragynine in Thai Kratom and significantly less in Indonesian Kratom varieties. But don’t underestimate the power of this lesser alkaloid – it’s far more potent than the effect of Mitragynine, prompting much interest in its use. Several sources compare the effects of 7-Hydroxymitragynine to the effects of morphine, providing a quick analogy of its strength.

Though Mitragynine also interacts with the mu opioid receptors in the body, it has a lesser affinity than the highly interactive 7-Hydroxymitragynine. Even in small quantities, 7-OH can significantly impact our well-being.

The potential effects of 7-Hydroxymitragynine are similar to that of Kratom and MIT, with two exceptions:

• 7-OH may have a more sedating effect.
• 7-OH is highly potent, and use must be closely monitored for safety.

Important Notes on the Metabolism of 7-Hydroxymitragynine

Some more white lab coat stuff on the 7-OH effects of Kratom use:

• 7-Hydroxymitragynine is a terpenoid indole alkaloid, a subset of indole alkaloids, with a complex (over 20 step!) biosynthesis.
• 7-Hydroxymitragynine is an active metabolite of Mitragynine. (This means that when you ingest Kratom, the Mitragynine metabolizes into 7-OH when it interacts with certain enzymes in the body.)
• 7-Hydroxymitragynine is a key mediator of its effects. (7-OH may “boost” the possible relieving effects of MIT.)
• The antinociceptive effect of 7-hydroxymitragynine is likely responsible for how it can provide such intense relief. This has been demonstrated in a laboratory environment testing the effect of 7-hydroxymitragynine in mice.
• 7-OH or (7HMG) demonstrates a greater affinity at the mu opioid receptors than Mitragynine. (This may be why 7-OH is estimated to be 14-22 times stronger than MIT.)

Key Distinctions Between Mitragynine and 7-Hydroxymitragynine

Given the different activities of Mitragynine and 7-Hydroxymitragynine, it makes sense that they’d impact us differently. While they are present in vastly different quantities in regular Kratom, nature has a way of designing things perfectly. 7-Hydroxymitragynine may be less stable in Kratom leaf, so your body naturally converts MIT into 7-OH. At least, this theory makes sense to us.

So, what are the key differences between Mitragynine and 7-Hydroxymitragynine, aside from their synthesis and in vivo mechanisms? Here are what we consider the most important differences between these two, which help outline their abuse liability and therapeutic potential:

1. Mitragynine’s abundance in Kratom preparations is more well-known and backed by centuries of anecdotal data. (Therefore, MIT within regular Kratom and in enhanced Kratom solutions is more trusted and understood by Kratom users, which may reduce its potential for overuse or abuse.)
2. Many Kratom users are unaware of the potency of 7-OH, and while its use may raise the therapeutic potential, this must be balanced against the risk of misusing this potent alkaloid.
3. Both alkaloids have faced legal issues. Federally, neither Mitragynine or 7-Hydroxymitragynine are labeled as controlled substances. A few states mitigate the use of Kratom’s active alkaloids specifically. Tennessee Kratom laws take an interesting stance, only allowing the alkaloids in their natural form, outlawing any lab-adulterated compounds being marketed as “Kratom”.
4. While both face legal battles, 7-Hydroxymitragynine has recently come under intense scrutiny as Kratom researchers question very high levels of 7-OH in Kratom products, citing it is unnatural and suggests adulteration in a lab. The AKA has also alluded to these concerns.

Kratom Use Tip: To have a safe and enjoyable Kratom experience with Kratom leaf products, use Kratom wisely. We’re here to help you do that, whether you buy from Kats Botanicals or not!

Understanding the Effects & Uses of Mitragynine vs 7-Hydroxymitragynine

Kratom has been used for centuries as a way to give “pep” in the steps of hard-working field hands in Southeast Asia. It wasn’t until relatively recently that Kratom misuse has called the plant-based supplement into scrutiny. Mistakes can be made when people take a substance before educating themselves on what it is and how to use it properly.

Our public stance as a leading Kratom supplier in the U.S. is that Kratom is an amazing botanical with a wide array of potential and that wise and mindful use is always best. Kratom is best in its natural form (no synthetics), and the right Kratom strain in the right hands is an equation for a more pleasurable and comfortable experience. This is why we believe that understanding the effects and uses of each Kratom product can enhance your Kratom experience.

Kats Botanicals is transparent on this in a few ways:

• Each product page will contain all the information you need to take our Kratom products responsibly.
  • MIT or 7-OH concentrations if they have been raised or are naturally higher (as with Maeng Da Kratom, our enhanced Kratom strains, and our Kratom extract products).
  • Information on recommended dosing.
  • Links to blogs that outline, in detail, how to use the products and what measures to take to keep your Kratom journey fresh, enjoyable, and safe.
  • We provide full product transparency by making our COAs available to the public.
• We perform small batch, third-party, extensive laboratory testing to be sure your Kratom products meet our high cGMP standards.
• We align with the AKA and advocate for the safe and legal use of Kratom, along with keeping industry standards high and ethical.

The Benefits of Full-Spectrum Kratom

One other point we’d love for you to take from this reading is the importance of taking full-spectrum Kratom products, and getting a feel for the various Kratom strains and how they make you feel, before sampling Kratom extract products. While Kratom extracts are a valuable tool, they are best used by seasoned Kratom users. This is the best way to include Kratom in your daily life and find the most applicable and efficacious Kratom products for your needs.

Most Natural Form – Full-spectrum Kratom is Mitragynine-dominant and contains the full suite of alkaloids, providing the most well-rounded experience.

Entourage Effect – Many researchers and Kratom enthusiasts swear by the combined, synergistic effects of Mitragynine + the other alkaloids, flavonoids, and terpenes found in Kratom leaf. They work together, enhancing each other and sometimes mitigating adverse effects when used in tandem.

Biphasic Effects of Kratom – Thanks to the biphasic effects of Kratom, you can often change your experience simply by adjusting your dosage. (Down for energy, up for relaxation.)

Kratom Alkaloid Adverse Effects

Many potential Kratom alkaloid adverse effects or side effects can be avoided simply by following the guidelines on how to use Kratom properly. That being said, there are a few common side effects, which are often minor and may go away when you get used to taking Kratom:

• Tummy upset or nausea
• Skin itching
• Sweating
• Dry mouth
• Constipation
• Increased urination
• Drowsiness

Consider stopping Kratom and contacting your medical professional if you experience any significant side effects or if adverse effects include:

• Vomiting
• Sustained loss of appetite

Watch Out for Synthetic Kratom Alkaloids

The AKA has warned consumers not to use synthetic alkaloids, specifically 7-Hydroxymitragynine. The known pharmacological effects of Kratom change dramatically when irresponsible Kratom vendors begin tampering with nature’s way. There’s no real “easy” way to spot fake alkaloids created in a lab, except to have an idea of what’s natural.

If you see a product that has way more 7-OH than is normal, you might have an idea that there’s been some lab-production of the alkaloids. Think of how much Kratom you’d have to have to extract enough 7-OH to fulfill a product with extremely high quantities.

Besides, Mitragynine has been found to naturally change into 7-OH as it metabolizes. Your body should get the 7-OH it needs as you take regular or MIT-enhanced Kratom. Enhanced 7-OH products that are all-natural are out there, but they may be expensive due to production time and costs.

7 Easy Ways to Boost How You Use Kratom Alkaloids

If you’ve been thinking of switching to a 7-OH product or trying our Enhanced MIT products, then we support your mindful Kratom journey as you define it. Kratom use and its effects are different for everyone!

More Kratom Options to Try

1. Kratom and Kava – Combining Kratom + Kava means you get the effects of Kratom, plus the calm and social ease associated with taking Kava. This is a dynamic duo in terms of plant-based serenity! See our Kratavfusion Kratom + Kava Shots.
2. Kratom and Orange Juice – If your Kratom isn’t hitting like it used to, try drinking a glass of OJ with it! Orange juice is like a magical boosting serum for Kratom’s effects. It’s called potentiation, and there are lots of different Kratom potentiators you can try.
3. Kratom and CBD – Many people continue their CBD regimens when beginning their Kratom journey. With such a broad application for both plant-based supplements, this partnership will likely continue inspiring wellness across the U.S.
4. Vary Kratom Strains – As with many other botanicals, your body can get used to the Kratom, and you don’t feel the effects as much with the same dose. Rather than continually raising your dose, try switching Kratom strains to shake things up.
5. Take Occasional Breaks – Another Kratom pro tip is to take breaks from taking Kratom. This can help you avoid a Kratom plateau.
6. Try Enhanced Kratom varieties – Kratom extracts or Kratom shots may be intimidating for some Kratom users. That’s why we have entire Kratom lines dedicated to potent Kratom strains you love, which are “enhanced” with just the right amount of added alkaloids.
7. Add 1/2 Kratom Gummy Between Doses – Kratom Gummies are a tasty way to get a little alkaloid boost when you need it. Take 1/2 a gummy in a pinch, or replace your Kratom dose with a full gummy. Relax and enjoy!

Takeaways on the Difference Between Mitragynine and 7-Hydroxymitragynine

Here are the big takeaways about Mitragynine and 7-Hydroxymitragynine in Kratom use.

• Kratom alkaloids provide the boost we feel when we take Kratom.
• Mitragynine and 7-Hydroxymitragynine are the two most important Kratom alkaloids, and each brings important effects to your Kratom experience.
• Both Mitragynine and 7-Hydroxymitragynine are present in natural Kratom, but there’s measurably less of the latter.
• 7-OH is considerably stronger than MIT. (Remember this if a Kratom product says it has tons of 7-OH in it.)
• Taking extra 7-OH isn’t necessary and may be more expensive. MIT naturally creates 7-OH metabolites as Kratom metabolizes in the body.
• There are lots of ways to get the most out of your Kratom use. From Kratom potentiators in your diet to sampling the different strains to keep your Kratom tolerance low, to switching out your dose with a tasty Kratom + Kava shot – we’re here to help you on your journey.

Practicing Mindful Use of High-Quality Kratom

For those of you searching for relief, discovering Kratom may give you renewed hope that things can get better. It’s important to understand the key difference between Mitragynine and 7-Hydroxymitragynine when selecting Kratom products and measuring your doses. Mindful, responsible Kratom use is key to having a safe and meaningful experience with this versatile herb. For more information on Kratom and its alkaloids or other plant-based solutions for your wellness, visit our Guidebook and join our Kratom Community.